eleonora grespan

Eng-PhD, Postdoctoral fellow at the CNR Institue of Neuroscience Padova, Italy


Institute of Neuroscience - National Research Council
Corso Stati Uniti 4
35127 Padova, Italy

Email: eleonora.grespan@in.cnr.it
Phone: +39 049 8295764
Fax: +39 049 8295763

about

I am a Researcher at the Institute of Neuroscience of the National Research Council (IN-CNR). My activity is based in Padua, Italy, where I work in the group of Andrea Mari.
The research activity of my group is focused on the development and application of model-based methods for the study of glucose-insulin metabolism, in particular for the assessment of insulin sensitivity and beta-cell function and for the analysis of tracer experiments. The main areas of application are diabetes, obesity and other metabolic disorders.


My current main research interests are:
Study of incretin effects in healthy and type 2 diabetic subjects through the use of mathematical models. The model hypothesizes and simulates the mechanism of action of incretins at the cellular level to reproduce and understand a variety of data in vivo; Realization of mathematical models of the β-cell that explain in vitro and in vivo findings with consistent mechanisms; Evaluation of the clinical implications of insulin secretory and sensitivity defects in cystic fibrosis.Image analysis to evaluate the effects of different differentiation protocols on nuclear morphology of human induced pluripotent stem cells

bio

Since March 2015: Postdoctoral Fellow at the Institute of Neuroscience (IN) of the National Research Council (CNR) in Padova (Italy)

July 2018-January 2019: Maternity leave

2015: Dr. Rer. Nat in Microsystems Engineering (University of Freiburg, Germany) and PhD in Industrial Engineering (University of Padova, Italy)

August 2014-February 2015: Maternity leave

October 2011-August 2014: Research Affiliate, Venetian Institute of Molecular Medicine (VIMM), Padova, Italy

October 2011-August 2014: PhD student, Dept. Industrial Engineering, (University of Padova, Italy) in the group of Prof. Nicola Elvassore. The PhD was in joint supervision with the Institute of Microsystems Engineering, (University of Freiburg, Germany)

March 2011-August 2014: PhD student in the group of Prof. Jürgen Rühe, Institute of Microsystems Engineering , (University of Freiburg, Germany)

September 2011-August 2014: member of the International Research Training Group (IRTG) “Soft Matter Science: Concepts for the Design of Functional Materials” between the universities of Freiburg and Strasbourg

2010: Master degree in Bioengineering, University of Padova, Italy. Final grade: 110/110 cum laude.

August 2009-December 2009: International Undergraduate Fellowship at Boston University (MA, USA, Department of Biomedical Engineering).

October 2007-March 2008: Erasmus student at at the Polytechnic of Madrid (Spain), Department of Telecommunications Engineering

July 2007: Bachelor degree in Biomedical Engineering, University of Padova, Italy. Final grade: 107/110.

publications

Scientific articles

1. C. Colombo, G. Alicandro, S. Gambazza, P. Mileto,
A. Mari, E. Grespan, E. Nazzari, M.C.Russo, A. Battezzati. Ventilation inhomogeneity is associated with OGTT-derived insulin secretory defects in cystic fibrosis. Pediatr Pulmonol, 2019, 54(2):141-149.

2. E. Grespan, G.G. Giobbe, F. Badique, K. Anselme, J. Rühe, N. Elvassore. Effect of geometrical constraints on human pluripotent stem cell nuclei in pluripotency and differentiation. Integr Biol, 2018, 21;10(5):278-289.

3. D.J. Morrison, G.M. Kowalski, E. Grespan, A. Mari, C.R. Bruce, G.D. Wadley. Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans. Am J Physiol Endocrin Metab, 2018 1;314(5):E503-E511.

4. E. Grespan, T. Giorgino, S. Arslanian, A. Natali, E. Ferrannini, A. Mari. Defective amplifying pathway of β-cell secretory response to glucose in type 2 diabetes: integrated modeling of in vitro and in vivo evidence. Diabetes, 2018, 67(3):496-506.

5. E.Grespan, E. Serena, S.Martewicz, V. Le Houerou, J. Rühe, and N. Elvassore. “Analysis of calcium transients and uniaxial contraction force in single human embryonic stem cell-derived cardiomyocytes on microstructured elastic substrate with spatially controlled surface chemistries”. Langmuir, 2016, 32(46):12190–12201.

Conference proceedings

1. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, A. Mari. The different mechanisms of action of GIP and GLP-1 explain their different efficacy as therapeutic agents in type 2 diabetes. Diabetologia, 2018; 61(suppl. 1): S250-S250, abstract 511.

2. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, A. Mari. A mathematical modelling of the beta-cell explaining in vitro and in vivo findings with consistent mechanisms. Diabetologia. 2016;59(suppl. 1):S261-S262, abstract 547.

3. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “A mathematical model of the β cell explaining in vitro and in vivo findings with consistent mechanisms.” Cardiovascular Endocrinology, 2016, Vol 5, Supplement 1.

4. A. Battezzati, G. De Carlo, G. Bedogni, A. Leone, R. De Amicis, S. Bertoli , C. Colombo, R. Guarise, G. Cervellin, G. Alicandro, L. Zazzeron, M.C .Russo, S. Loi, C. Speziali, A. Bisogno, A. Mari, E. Grespan. “Clinical implications of the natural history of insulin secretory and sensitivity defects in cystic fibrosis.” Journal of Postdoctoral Research, December 2015, Vol 3, Number 12.

Oral Presentations at National and International conferences

1. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “The different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in diabetes”. Islet Society meeting (5th-6th September 2019), Maribor, Slovenia.

2. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “The different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in diabetes”. EASD Incretin Study Group meeting (24th-26th January 2019), Bochum, Germany.

3. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “Mechanisms of the impaired incretin action in type 2 diabetes: a modelling study”. European Group for the study of Insulin Resistance (EGIR) meeting (7th-8th June 2018), Lille, France.

4. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “Mechanisms of the impaired incretin action in type 2 diabetes: a modelling study”. Annual retreat of CNR Institute of Neuroscience (28th-30th September 2017), Santa Margherita di Pula, Italy.

5. E. Grespan, T. Giorgino, A. Natali, E. Ferrannini, and A. Mari. “A mathematical model of the β cell explaining in vitro and in vivo findings with consistent mechanisms.” EGIR meeting (12-14th May, 2016), Pisa, Italy.

6. E. Grespan, S. Martewicz, P. Pavan, V. Le Houerou, O. Prucker, J. Rühe and N. Elvassore, "Simultaneous study of calcium dynamics and contraction force in single-cardiomyocytes using polymeric micropatterned substrates". ESB 2013, Madrid, Spain.

7. E. Grespan, S. Martewicz, P.Pavan, V. Le Houerou, J. Rühe and N. Elvassore, "Contraction force of single-cardiomyocyte evaluated through the use of microstructurated elastic substrates combined with the study of calcium dynamics". GRICU 2012, Pescara, Italy.